Ivermectin

What is Ivermectin?

Ivermectin is a common drug used in the field of Canine Science. It's well known for its role in preventing heartworm diseases in dogs. First discovered and developed in the late 1970s, Ivermectin belongs to a class of drugs known as antiparasitics, offering wide-reaching protection against a variety of parasites.

How does Ivermectin work?

Ivermectin works by interfering with the nervous system and muscles of parasites, leading to their paralysis and death. The drug increases the release of a neurotransmitter called gamma-aminobutyric acid (GABA). This transmitter inhibits the normal functions of the parasite's nerve cells, resulting in paralysis and death of the parasite.

Ivermectin usage in dogs

In Canine Science, Ivermectin is used to prevent heartworm disease and to treat various other parasite-related conditions such as demodectic and sarcoptic mange, and ear mites. However, it's advised to use Ivermectin only after a professional prescription, because some dog breeds have a high susceptibility to Ivermectin due to a mutation in the MDR1 gene.

Understanding Ivermectin sensitivity in certain dog breeds

Many collie breeds such as Border Collies, Shetland Sheepdogs, and Australian Shepherds, have a genetic mutation that makes them sensitive to Ivermectin. This DNA abnormality affects the transport of the drug into the brain. In these breeds, Ivermectin can pass the dog's blood-brain barrier and lead to drug toxicity, potentially resulting in serious neurological issues and even death. Therefore, dosage and usage of Ivermectin should be properly guided by a veterinarian.

The vital role of Ivermectin in Canine Science

Despite the risks in certain breeds, Ivermectin remains a powerful tool in Canine Science. The drug's broad spectrum anti-parasitic action plays a vital role in improving and maintaining the health of dogs worldwide. It’s essential both for preventive and therapeutic purposes in canine medicine, always under the strict guidance of a veterinary professional.